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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Type III Interferons: Emerging Roles in Autoimmunity.

Sindhu Manivasagam1,2, Robyn S Klein1,2,3,4

  • 1Center for Neuroimmunology & Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, United States.

Frontiers in Immunology
|December 13, 2021
PubMed
Summary
This summary is machine-generated.

Type III interferons (IFNLs) are crucial for immune defense at barriers. IFNL signaling influences T cell differentiation and may be a therapeutic target for autoimmune diseases.

Keywords:
IFNLRTh1 cellsautoimmune diseasesinterferon lambdaneuroimmunology and neuropathology

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Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Type III interferons (IFNLs) are cytokines vital for antimicrobial immunity at epithelial and endothelial barriers.
  • IFNLs signal through a heterodimeric receptor (IFNLR1/IL10Rβ), dictating cellular response specificity.

Purpose of the Study:

  • To summarize IFNL signaling pathways in antimicrobial immunity.
  • To review IFNL-mediated immunomodulation of innate and adaptive immune cells.
  • To discuss the role of IFNL in the induction of autoimmunity.

Main Methods:

  • Literature review of studies on Type III interferon signaling.
  • Analysis of IFNL's role in immune cell differentiation and function.
  • Examination of IFNL's involvement in autoimmune disease pathogenesis.

Main Results:

  • IFNL signaling promotes Th1 cell differentiation.
  • IFNLs modulate both innate and adaptive immune responses.
  • IFNL pathways are implicated in the development of autoimmunity.

Conclusions:

  • IFNL signaling is a key regulator of host defense and immune homeostasis.
  • The role of IFNL in T cell differentiation highlights its potential as a therapeutic target for autoimmune disorders.