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Evolution of plasma vitamin B12 in patients with solid cancers during curative versus supportive care
Valentin Lacombe1, Anne Patsouris2, Estelle Delattre1
1Department of Internal Medicine and Clinical Immunology, University Hospital, Angers, France.
Introduction:
The direction of the causal link between solid cancers and elevated plasma vitamin B12 (B12) remains uncertain.
Methods:
We retrospectively included patients having two B12 measurements with a B12 initially ≥ 1000 ng/l and a solid cancer diagnosed between the measurements. Patients were included in the Curative or Supportive group according to their treatments.
Results:
B12 changes over time differed between groups (p = 0.001): +157.4 ng/l/month in the Supportive care group versus -171.6 ng/l/month in the Curative care group.
Conclusions:
The decrease of plasma B12 in cases of curative care could suggest that this B12 elevation is secondary to solid cancers.
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