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Related Experiment Video

Updated: May 20, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Exploring glucocorticoid dose-response patterns in VEXAS syndrome: a pilot retrospective study.

Nicolas Giachetti1, Jérome Hadjadj2,3, Noémie Gaudré4

  • 1Médecine interne - Immunologie clinique, Centre National de Référence Maladies Auto-immunes Systémiques Rares du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM-Angers), CHU d'Angers, Angers, France.

Rheumatology International
|May 19, 2026
PubMed
Summary

Glucocorticoid (GC) dose impacts VEXAS syndrome activity and flares. Higher GC doses correlate with lower disease activity, with flare risk increasing below 15 mg/day.

Keywords:
UBA1 mutationDisease flareGlucocorticoid dependenceGlucocorticoid taperingSteroid-sparing therapiesVEXAS syndrome

Related Experiment Videos

Last Updated: May 20, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • VEXAS syndrome requires high glucocorticoid (GC) doses.
  • GC dose-response patterns in VEXAS syndrome are not well-defined.
  • Frequent relapses occur during GC tapering.

Purpose of the Study:

  • Assess feasibility of granular treatment-line reconstruction in VEXAS syndrome.
  • Explore GC dose-response patterns related to disease activity.
  • Investigate GC dose effects on flare risk.

Main Methods:

  • Retrospective single-center pilot study.
  • Reconstructed detailed treatment trajectories for 12 VEXAS patients.
  • Analyzed GC dose, concomitant therapies, and clinical activity using multivariable models.

Main Results:

  • Higher GC dose was independently associated with lower clinical activity (aOR 0.91).
  • Flare risk increased below ~15 mg/day GC, with a plateau above 20 mg/day.
  • Organ-specific GC sensitivity varied; lung involvement required higher doses.

Conclusions:

  • Detailed treatment-line reconstruction is feasible in VEXAS syndrome.
  • Identified GC dose-response trends and potential flare thresholds.
  • Findings inform future studies on VEXAS syndrome GC tapering strategies.