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Updated: Oct 10, 2025

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Diastolic Dysfunction Is a Predictor of Poor Survival in Patients with Decompensated Cirrhosis

Manas Kumar Behera1, Surendra Nath Swain2, Manoj Kumar Sahu1

  • 1Department of Gastroenterology, IMS and SUM Hospital, Bhubaneswar, India.

International Journal of Hepatology
|December 13, 2021
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is an early sign in cirrhosis. This study shows LVDD and low albumin predict mortality in decompensated cirrhosis patients, indicating advanced disease.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Left ventricular diastolic dysfunction (LVDD) is an early cardiac abnormality in cirrhosis.
  • LVDD severity impacts outcomes of liver transplantation and TIPS insertion.
  • Few Indian studies have explored LVDD's role in decompensated cirrhosis survival.

Purpose of the Study:

  • To assess the impact of LVDD on the survival of decompensated cirrhotic patients.
  • To identify predictors of mortality in this patient group.

Main Methods:

  • Prospective evaluation of 92 decompensated cirrhotic patients.
  • Utilized 2D echocardiography with tissue Doppler imaging to assess cardiac function.
  • Primary endpoint: effect of LVDD on overall mortality over 24 months.

Main Results:

  • 30% of patients (28/92) died within 24 months.
  • Higher E/e' ratio (≥10) correlated with higher MELD and Child-Pugh scores, indicating severe LV dysfunction.
  • Cox analysis identified E/e' ratio ≥10 and low serum albumin as independent mortality predictors.

Conclusions:

  • LVDD and low serum albumin are independent predictors of mortality in decompensated cirrhosis.
  • LVDD signifies advanced cirrhosis and increased mortality risk.
Abstract

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