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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Oct 10, 2025

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Choroidal neovascularization complicating sclerochoroidal calcifications.

Maurizio Battaglia Parodi¹, Alessandro Arrigo¹, Adelaide Pina¹

¹Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.

American Journal of Ophthalmology Case Reports

|December 13, 2021

Summary

Sclerochoroidal calcifications (SCC) can lead to choroidal neovascularization (CNV). Intravitreal anti-VEGF injections effectively managed CNV in SCC patients, improving visual acuity.

Keywords:

Choroidal neovascularization FAF Multimodal imaging OCT OCTA Sclerochoroidal calcification

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Published on: August 9, 2024

Area of Science:

Ophthalmology
Medical Imaging
Vascular Biology

Background:

Sclerochoroidal calcifications (SCC) are rare scleral deposits.
Choroidal neovascularization (CNV) is a potential complication of SCC.

Observation:

Two cases of SCC complicated by CNV were identified.
Multimodal imaging, including OCTA, was used for diagnosis.
Fundus examination revealed characteristic lesions with exudation.

Findings:

CNV diagnosis was confirmed via fluorescein angiography and OCTA.
Patients received ranibizumab injections over a six-year period.
Final best-corrected visual acuity (BCVA) improved to 20/25 with CNV stabilization.

Implications:

SCC can present with or lead to CNV.
Intravitreal anti-VEGF therapy offers a viable treatment for CNV in SCC.
Prompt management can lead to significant visual recovery.