Related Experiment Video
Updated: Oct 10, 2025
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A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
Published on: August 30, 2019
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Experimental asynchrony to study self-inflicted lung injury.
John N Cronin1, Federico Formenti2
1Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, King's College London, London, UK; Department of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, UK.
British Journal of Anaesthesia
|December 14, 2021
Summary
Patient self-inflicted lung injury (PSILI) may not be caused by patient-ventilator asynchrony (PVA). New research suggests PVA might be a marker, not a cause, of PSILI, requiring further investigation.
Area of Science:
- Critical care medicine
- Respiratory physiology
- Translational research
Background:
- Patient self-inflicted lung injury (PSILI) is linked to adverse outcomes.
- Patient-ventilator asynchrony (PVA) is hypothesized as a mechanism for PSILI.
- Previous studies were observational, lacking causal evidence.
Discussion:
- Wittenstein et al. developed a novel method to control PVA in an acute lung injury pig model.
- This experimental approach aimed to establish causality between PVA and PSILI.
- Findings challenge the direct causal role of PVA in PSILI.
Key Insights:
- Increased PVA in observational studies may be a marker, not the cause, of PSILI.
- Experimental data suggests PVA does not directly cause PSILI.
- This reframes the understanding of PVA's role in lung injury.
Outlook:
- Further experimental research is needed to confirm these findings.
- Clinical studies are required to assess the implications for patient care.
- Current evidence is insufficient to alter clinical tolerance of PVA.
