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Functional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal
Julie C Reid1, Andrew P Costa2,3,4,5,6, MyLinh Duong2
1School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Insights
This study tracks functional recovery in hospitalized COVID-19 patients for up to 12 months. Findings will inform clinical care for long-term COVID-19 recovery and mobility limitations.
Area of Science:
- Public Health
- Infectious Diseases
- Rehabilitation Medicine
Background:
- COVID-19 presents a global health crisis with over 132 million cases.
- Persistent sequelae, including mobility issues and fatigue, are reported in COVID-19 survivors.
- Limited evidence exists on the functional recovery trajectory post-hospitalization for COVID-19.
Purpose of the Study:
- To understand the medium and long-term functional recovery trajectory in individuals hospitalized with COVID-19.
- To guide clinical care and optimize management strategies for COVID-19 recovery.
- To establish a data platform for future COVID-19 recovery research.
Main Methods:
- Multicenter longitudinal cohort study (Coronavirus Registry Functional Recovery - COREG-FR).
- Enrolled 211+ adults hospitalized with COVID-19, followed up to 12 months post-discharge.
- Assessed physical and lung function using the Activity Measure for Post-Acute Care mobility scale; analyzed using linear mixed effects regression.
Main Results:
- This is a pre-results abstract, so no findings are available yet.
- The study is registered under NCT04602260.
- Data collection and analysis are ongoing.
Conclusions:
- The COREG-FR study will provide crucial insights into the functional recovery of hospitalized COVID-19 patients.
- Findings will inform clinical practice and enhance patient management during the recovery phase.
- The study aims to contribute to a better understanding of long-term COVID-19 sequelae.
Introduction:
COVID-19 is an international public health crisis with more than 132 million infections worldwide. Beyond acute infection, emerging data indicate patients diagnosed with COVID-19 may experience persistent sequelae similar to survivors of sepsis or acute respiratory syndromes, including mobility limitations and fatigue. However, there is limited evidence on the trajectory of functional recovery in those hospitalised with COVID-19. The primary aim of the Coronavirus Registry Functional Recovery (COREG-FR) study is to understand the trajectory of functional recovery among individuals hospitalised for COVID-19 over the medium (up to 6 months) and longer term (6-12 months) that will guide clinical care and optimal management of serious COVID-19 illness and recovery.
Methods And Analysis:
COREG-FR is a multicentre longitudinal cohort study. We will enrol a minimum of 211 adults age 18 years and older with COVID-19 from five hospitals. Participants will be followed from admission to hospital as an inpatient, to hospital discharge, and at 3-month, 6-month, 9-month and up to 12-month post-hospital discharge. We will conduct telephone interviews at ward admission and discharge, and telephone interviews plus in-person assessments of physical function and lung function at all remaining follow-ups. Our primary outcome is the Activity Measure for Post-Acute Care mobility scale measured at all time points. We will conduct linear mixed effects regression analyses to explore determinants of functional outcomes after COVID-19 illness. Subgroup analyses based on age (≤65 vs >65 years), frailty status (Clinical Frailty Scale score ≤4 vs >5) and variants of concern will be conducted.
Ethics And Dissemination:
COREG-FR has been approved by Research Ethics Boards at participating sites. We will disseminate this work through peer-reviewed manuscripts, presentations at national and international meetings and through the established COREG website (www.coregontario.ca). COREG-FR is designed as a data platform for future studies evaluating COVID-19 recovery.
Trial Registration Number:
NCT04602260; Pre-results.
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