Related Experiment Video
Updated: Oct 10, 2025

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
PHIST: fast and accurate prediction of prokaryotic hosts from metagenomic viral sequences
Andrzej Zielezinski1, Sebastian Deorowicz2, Adam Gudyś2
1Department of Computational Biology, Adam Mickiewicz University, Poznan 61-614, Poland.
Summary:
Phage-Host Interaction Search Tool (PHIST) predicts prokaryotic hosts of viruses based on exact matches between viral and host genomes. It improves host prediction accuracy at species level over current alignment-based tools (on average by 3 percentage points) as well as alignment-free and CRISPR-based tools (by 14-20 percentage points). PHIST is also two orders of magnitude faster than alignment-based tools making it suitable for metagenomics studies.
Availability And Implementation:
GNU-licensed C++ code wrapped in Python API available at: https://github.com/refresh-bio/phist.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
More Related Videos
Related Concept Videos
Viruses of Archaea
Modern Molecular Taxonomy
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Genomic DNA in Prokaryotes
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Evolutionary Relationships through Genome Comparisons

