Related Experiment Video
Updated: Oct 10, 2025
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
Published on: August 18, 2016
Comparative study of plasma clearance of iohexol at different injection doses
Ke Gong1, Yingshu Zou2, Haifeng Zhu3
1Department of Clinical Laboratory, Civil Aviation General Hospital, Beijing, China; Peking University Civil Aviation School of Clinical Medicine, Beijing, China.
Background:
Our goal was to compare the metabolic curves of plasma clearance of iohexol (ClIOH) at standard dose (5 ml) and contrast-level dose (50 ml).
Methods:
The concentration of iohexol was measured at fasting state and at nine different time periods after a single bolus of iohexol injection. The interval between the injection of the two doses was longer than 24 hrs. Using a multi-point method and a dual-sample method, ClIOH-M and ClIOH-D were calculated, and the correlation and consistency of ClIOH between the two doses were compared.
Results:
The metabolic curves of iohexol at the 5 ml and 50 ml injection were substantially identical. The correlation of ClIOH-M between the two doses was 0.930, the mean deviation was 1.3 ± 6.9 ml/min/1.73 m2. Taking ClIOH-5ml-M as the standard, the ClIOH-50ml-D at 2 h and 4 h had a correlation coefficient of 0.975, a mean deviation of 0.1 ± 5.3 ml/min/1.73 m2, and the concordances were 100% corresponding to P30, 88.9% corresponding to P10, and 77.8% corresponding to P5.
Conclusion:
When a regular dose of iohexol is used for enhanced CT, ClIOH can be used for the measurement of GFR, and a proper time for blood collection can be 2 h and 4 h.
Related Concept Videos
00:56One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
01:18Two-Compartment Open Model: IV Bolus Administration
The disparity between drug input and the sum of drug transfer rates between...
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
01:09One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
00:59Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...