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Chitosan: A versatile bio-platform for breast cancer theranostics
Vijay Sagar Madamsetty1, Shima Tavakol2, Saeid Moghassemi3
1Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL 32224, USA.
Summary
Chitosan nanotechnology offers a promising new avenue for breast cancer treatment. This biocompatible polymer serves as an effective drug carrier and theranostic agent, potentially leading to improved clinical outcomes.
Area of Science:
- Biomaterials Science
- Nanomedicine
- Oncology
Background:
- Breast cancer remains a leading cause of cancer-related deaths globally, with current treatments exhibiting limited efficacy and significant side effects.
- Existing diagnostic and therapeutic strategies for breast cancer, including chemotherapy and immunotherapy, necessitate the development of novel, safer, and more effective approaches.
Purpose of the Study:
- To explore the potential of chitosan-based nanotechnology in advancing breast cancer diagnostics and therapeutics.
- To review the application of chitosan as a drug delivery system for various anticancer agents and its role in theranostics.
Main Methods:
- Review of existing literature on chitosan derivatives and their applications in cancer therapy.
- Analysis of studies focusing on chitosan nanoformulations for drug delivery and theranostic purposes.
Main Results:
- Chitosan, a biocompatible polymer, demonstrates significant potential as a nano-carrier for delivering anticancer drugs like tamoxifen and doxorubicin.
- Chitosan-based nanoformulations show promise for both therapeutic drug delivery and theranostic applications, including photo-responsive and thermo-responsive systems.
Conclusions:
- Chitosan-based nanotechnology presents a promising platform for the development of novel breast cancer treatments.
- The therapeutic and theranostic capabilities of chitosan suggest a strong potential for its translation into clinical practice for cancer management.
