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Related Experiment Video

Updated: Oct 10, 2025

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
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MYTHS AND TRUTHS OF THE ASSOCIATION OF RETINAL VASCULAR OCCLUSION WITH COVID-19.

Ashish Sharma1, Nikulaa Parachuri1, Nilesh Kumar1

  • 1Lotus Eye Hospital and Institute, Coimbatore, Tamil Nadu, India.

Retina (Philadelphia, Pa.)
|December 15, 2021
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Summary

This review found insufficient evidence to link COVID-19 to retinal vascular occlusion. More robust data is needed before altering current clinical management guidelines for retinal vein or artery occlusion.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • COVID-19 has been anecdotally associated with various vascular complications.
  • Retinal vascular occlusions (RVOs) are serious conditions affecting vision.

Purpose of the Study:

  • To critically evaluate existing literature for a causal link between COVID-19 and retinal vascular occlusions.
  • To determine if current evidence supports a definitive association.

Main Methods:

  • Comprehensive literature search on PubMed using keywords: retinal vascular occlusion, retinal vein occlusion, retinal artery occlusion, and COVID-19.
  • Analysis of 17 case reports published during the review period.

Main Results:

  • 17 case reports were identified (10 RVO, 7 RAAO).
  • Most reports lacked strong evidence due to insufficient laboratory workup or confounding risk factors.
  • No definitive causal link could be established.

Conclusions:

  • Current data is insufficient to establish a cause-and-effect relationship between COVID-19 and retinal vascular occlusive disorders.
  • Clinicians should continue standard management protocols for RVO and RAAO in the absence of robust evidence supporting an altered approach.