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Updated: Oct 10, 2025
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Comparison Between Different Segmentation Strategies for the Choriocapillaris Using Optical Coherence Tomography
Background And Objective:
To assess the relationship between retinal pigment epithelium (RPE) and RPE fit-based segmentations of the choriocapillaris (CC) and its expected anatomic location.
Patients And Methods:
Consecutive healthy participants' eyes were imaged with optical coherence tomography angiography (PLEX Elite) with 3 × 3-mm and 6 × 6-mm scan. Ground-truth images were generated using 16-μm-thick slabs starting from 4 μm below the automatically segmented Bruch's membrane (BM) band. A series of slabs positioned below the RPE band and RPE fit were also generated, and CC flow deficit percentage was compared with the ground-truth segmentation.
Results:
Twenty-six eyes of 26 participants were analyzed. For both scans, the 21 to 37-μm slab offset from the RPE band most closely matched the BM-based ground-truth slab with mean differences of 0.78% and 0.36%.
Conclusion:
The CC flow deficit percentage from the RPE band correlated strongly with BM-based CC slabs, with the closest approximation observed with slab offset 21 to 37 μm from the RPE band centerline. [.
