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Total synthesis of remdesivir
Kishore Kumar Palli1,2, Palash Ghosh1,2, Shiva Krishna Avula1,2
1Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India.
Tetrahedron Letters
|December 15, 2021
Summary
A new, simplified synthesis of remdesivir, an important COVID-19 treatment, has been developed. This efficient method reduces protecting group steps, making remdesivir more accessible for patients with SARS-CoV-2 infections.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Virology
Background:
- Remdesivir is a critical antiviral medication for treating COVID-19.
- High demand for remdesivir necessitates efficient and scalable synthetic routes.
- Current synthetic methods may involve complex protecting group strategies.
Purpose of the Study:
- To develop a more facile and efficient synthetic approach for remdesivir.
- To minimize the number of protecting group manipulations in the remdesivir synthesis.
- To achieve a good overall yield of remdesivir.
Main Methods:
- A novel synthetic strategy for remdesivir was designed.
- Key steps focused on reducing protecting group manipulations.
- The synthesis was optimized for yield and efficiency.
Main Results:
- The developed approach successfully afforded remdesivir.
- The synthetic route minimized protecting group manipulations.
- A good overall yield of remdesivir was achieved.
Conclusions:
- The reported facile approach offers an improved synthesis of remdesivir.
- This method has the potential to enhance the accessibility of remdesivir for COVID-19 treatment.
- Further optimization could lead to large-scale production advantages.
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