Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

472
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
472
Neural Regulation01:37

Neural Regulation

40.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.5K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

890
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
890
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

537
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
537
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

97.8K
Overview
97.8K
Hormonal Regulation01:40

Hormonal Regulation

44.9K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
44.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 3D-bioprinted hydrogel platform with tunable matrix stiffness reveals mechanical adaptation and doxorubicin resistance in triple-negative breast cancer.

Journal of materials chemistry. B·2026
Same author

Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement.

Nature biomedical engineering·2026
Same author

Next-generation immune models: bioinks, 3D bioprinting, and future directions.

Trends in biotechnology·2026
Same author

Risperidone redefined: A three-decade odyssey of broadening indications and evolving formulations.

Medical journal, Armed Forces India·2026
Same author

Immediate NExT rollout is vital for MBBS students and the medical education ecosystem of India.

Journal of family medicine and primary care·2026
Same author

Hemostatic Sponge Based on Modified Alginate and Water-Soluble Chitosan for Rapid Hemorrhage Control.

ACS biomaterials science & engineering·2026

Related Experiment Video

Updated: Oct 10, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.9K

Gut-brain axis: Synergistic approach.

Markanday Sharma1, Jyoti Prakash1, Prateek Yadav1

  • 1Department of Psychiatry, Armed Forces Medical College, Pune, Maharashtra, India.

Industrial Psychiatry Journal
|December 15, 2021
PubMed
Summary
This summary is machine-generated.

The gut-brain axis involves bidirectional communication between gut microbes and the brain, influencing neurological and psychiatric conditions. Understanding this connection offers new therapeutic strategies for brain disorders.

Keywords:
Enteric nervous systemgut–brain axismicrobiotapsychiatric disorder

More Related Videos

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

775
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.4K

Related Experiment Videos

Last Updated: Oct 10, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.9K
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

775
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.4K

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • The concept of the gut-brain axis has evolved, with increasing evidence supporting bidirectional communication between the gut microbiome and the brain.
  • This axis is crucial for understanding the biological and physiological basis of psychiatric, neuro-developmental, age-related, and neurodegenerative disorders.
  • Factors like age and stress significantly impact gut microbiota composition and its influence on the gut-brain axis.

Purpose of the Study:

  • To explore the intricate mechanisms underlying the gut-brain axis.
  • To highlight the role of gut microbiota in various neurological and psychiatric conditions.
  • To identify potential intervention and therapeutic strategies for neuropsychiatric disorders based on microbiota modulation.

Main Methods:

  • Review of current scientific literature on the gut-brain axis and microbiota.
  • Analysis of studies investigating the link between gut microbiota and brain function.
  • Examination of emerging therapeutic approaches targeting the gut microbiome.

Main Results:

  • The gut microbiome plays a significant role in conditions such as severe mental illness, autism, anxiety, obesity, Parkinson's disease, and Alzheimer's disease.
  • Bidirectional communication pathways between the gut and brain are increasingly recognized.
  • Stress is identified as a key factor influencing the gut-brain axis throughout life.

Conclusions:

  • The gut-brain axis represents a critical area of research for understanding and treating a wide range of brain disorders.
  • Modulating the gut microbiota holds promise as a therapeutic strategy for neuropsychiatric conditions.
  • Further research into the underlying mechanisms is essential for developing effective interventions.