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Diabetes Mellitus: Type 2 and Gestational01:22

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Intermittent Fasting: A User-Friendly Method for Type 2 Diabetes Mellitus.

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  • 1Internal Medicine, Jamal Noor Hospital, Karachi, PAK.

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Intermittent fasting (IF) shows promise for managing type 2 diabetes by improving glycemic control and insulin resistance. This dietary strategy may help reduce obesity and inflammation, offering a cost-effective approach to T2DM management.

Keywords:
fastingglycated hemoglobin (hba1c)intermittent fastingreligious fastingtherapeutic fastingtype 1 diabetes mellitustype 2 diabetes mellitusweight loss and obesity

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Nutritional Science

Background:

  • Type 2 diabetes mellitus (T2DM) is a growing global health concern characterized by insulin resistance and hyperglycemia.
  • Elevated blood glucose levels in T2DM can lead to severe complications, emphasizing the need for effective management strategies.
  • Dietary interventions are central to T2DM pathogenesis and management, with intermittent fasting (IF) emerging as a key area of research.

Purpose of the Study:

  • To investigate the efficacy of intermittent fasting (IF) as a therapeutic strategy for managing type 2 diabetes mellitus (T2DM).
  • To explore the physiological effects of various IF regimens on glycemic control, insulin resistance, and associated metabolic parameters.
  • To examine the potential role of sirtuin-6 (SIRT6) proteins in mediating the benefits of IF for T2DM.

Main Methods:

  • Review of case studies and randomized trials evaluating different intermittent fasting regimens (e.g., alternate-day, religious, time-restricted fasting).
  • Analysis of IF's impact on key metabolic markers including blood glucose, HbA1c, visceral fat, and inflammatory mediators (CRP, IL-6).
  • Exploration of the proposed mechanism involving sirtuin-6 (SIRT6) protein upregulation and its effect on insulin sensitivity.

Main Results:

  • Intermittent fasting demonstrates significant potential for improving glycemic control and reversing insulin resistance in T2DM patients.
  • Studies indicate IF can lead to reductions in visceral fat, C-reactive protein (CRP), and interleukin-6 (IL-6) levels.
  • Observed reductions in HbA1c levels post-fasting are potentially linked to increased sirtuin-6 (SIRT6) protein activity.

Conclusions:

  • Intermittent fasting is a promising, cost-effective, and patient-compliant strategy for managing type 2 diabetes mellitus.
  • IF may offer therapeutic benefits by enhancing insulin sensitivity and improving overall metabolic health.
  • Further research into the SIRT6 protein pathway could unlock new therapeutic targets for T2DM treatment.