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MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION

Luciana Rodrigues da Cunha1,2, Maria Carolina Magalhães de Castro1, Gabriela Silva Duarte1

  • 1Universidade Federal de Minas Gerais, Faculdade de Medicina, Ambulatório de Hepatites Virais, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.

Arquivos De Gastroenterologia
|December 15, 2021
PubMed

Insights

Major depressive disorder (MDD) is common in chronic hepatitis C (CHC) patients. This study found MDD is linked to type 2 diabetes and younger age in CHC patients, highlighting the need for psychiatric screening.

Area of Science:

  • Hepatology
  • Psychiatry
  • Internal Medicine

Background:

  • Major depressive disorder (MDD) frequently co-occurs with chronic hepatitis C (CHC).
  • The underlying factors contributing to this comorbidity remain incompletely understood.
  • Understanding these factors is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine the prevalence of mental disorders in CHC patients.
  • To identify specific variables associated with MDD in this population.
  • To inform clinical screening and management strategies.

Main Methods:

  • A cohort of 151 CHC patients was assessed.
  • Psychiatric diagnoses were evaluated using the Mini-International Neuropsychiatry Interview.
  • The Cut-Annoyed-Guilty-Eye (CAGE) Questionnaire was employed.
  • Multivariate analysis identified independent predictors of current MDD.

Main Results:

  • Over half (50.3%) of CHC patients had at least one psychiatric diagnosis.
  • MDD was the most prevalent diagnosis, affecting 33.1% of patients.
  • Current MDD was significantly associated with younger age (≤50 years) and type 2 diabetes mellitus.
  • Cirrhosis was linked to type 2 diabetes and current alcohol abuse/dependence.

Conclusions:

  • Type 2 diabetes is a significant comorbidity associated with MDD in CHC patients.
  • Despite advancements in hepatitis C treatment (direct-acting antivirals), psychiatric screening remains essential.
  • Routine clinical care for CHC patients should include screening for mental health disorders.
Abstract

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