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Updated: Oct 10, 2025

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Published on: April 19, 2024
Trigger performance of five pediatric home ventilators and one ICU ventilator depending on circuit type and system
Jana Baumgartner1, Johanna Schmidt2, Daniel Klotz1
1Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Insights
Choosing the right home ventilator for children with chronic respiratory failure is challenging. This study found significant differences in ventilator trigger performance based on circuit type and system leak size.
Area of Science:
- Pediatric respiratory care
- Biomedical engineering
- Mechanical ventilation
Background:
- The number of children requiring home mechanical ventilation for chronic respiratory failure is increasing globally.
- Selecting appropriate home ventilators for pediatric patients presents a challenge for clinicians.
- This study addresses the need for comparative data on pediatric home ventilator performance.
Purpose of the Study:
- To compare the trigger performance of various pediatric bilevel home ventilators and an intensive care unit ventilator.
- To evaluate the impact of different circuit types and system leak on ventilator trigger function.
Main Methods:
- A physical lung model was used to test five pediatric bilevel home ventilators and one ICU ventilator.
- Ventilators were evaluated with compatible circuits under varying system leak conditions.
- Simulated patient breathing effort was applied with specific flow rates and respiratory frequency.
Main Results:
- Significant variations in trigger performance were observed among the evaluated ventilators.
- Trigger thresholds, pressure rise times, and trigger work differed notably between devices.
- Leak compensation effectiveness was dependent on the circuit type, not the circuit's internal diameter.
Conclusions:
- The triggering performance of home ventilators for pediatric patients varies considerably.
- Optimal ventilator-circuit selection should account for patient-specific factors like age, condition, and potential for system leaks.
- Clinicians need to consider these performance differences when choosing home ventilation equipment.
Background:
The population of children with chronic respiratory failure requiring long-term mechanical ventilation in the home has grown worldwide. The optimal choice from an increasing number of home ventilators commercialized for children is often challenging for the attending physicians. The aim of the present study was to compare the trigger performance of five pediatric bilevel home ventilators and one intensive care unit ventilator depending on circuit type and system leak.
Methods:
The trigger performances of the ventilators were compared in combination with all compatible circuits using a physical model of the lung with increasing system leak. The flow generator simulated the patient's breathing effort with flow rates of 2.7-6.4 L/min at a frequency of 30 breaths/min. All ventilators were set to deliver 16 cmH2 O inspiratory pressure support and 4 cmH2 O positive end-expiratory pressure.
Results:
Trigger thresholds varied from 1.5 to 8 L/min, the pressure rise time to 90% of the maximum from 140 to 385 ms and the trigger work from 0.5 to 6.6 mbar · s. All devices had very short trigger delays below 40 ms. The leak compensation depended on the circuit type. The internal diameter of the circuit had no relevant impact on the trigger performance or the leak compensation.
Conclusion:
We observed considerable differences in the triggering performance of the evaluated home ventilators depending on leak size and type of circuit. Therefore, an optimal combination of device and circuit should consider the patient's age and condition and the probability of system leak.
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