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Updated: Oct 10, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Extraglomerular immune complex deposition in lupus nephritis
Valentina Papa1, James Brainer2, Kammi J Henriksen2
1Biomedical and Neuromotor Sciences Department, 9296Alma Mater University of Bologna, Bolgana, Italy.
Background:
Lupus nephritis (LN) is a common manifestation and a major cause of morbidity and mortality in systemic lupus erythematosus (SLE) patients. It is characterized by glomerular and often extraglomerular immune complex deposition.
Purpose:
Given the emerging importance of the tubulointerstitial compartment, we conducted a retrospective study of 78 LN biopsies to enumerate the spectrum of extraglomerular immune complex deposition that can be observed in lupus nephritis by electron microscopy and to identify possible clinical or pathologic correlates.
Results:
The presence of tubulointerstitial immune complex deposition often accompanied interstitial inflammation, but some discrepancies were also seen.
Conclusions:
As target antigens are identified, correlation with glomerular, tubulointerstitial, and vascular immune complex deposition will be of increasing interest.
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