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Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure

Hongli Li1, Fangfang Zhang2, Dan Zhang3

  • 1Hongli Li, Department of Cardiology, Baoding First Central Hospital, Baoding, Hebei 071000, China.

Pakistan Journal of Medical Sciences
|December 16, 2021
PubMed

Insights

Serum ficolin-3 levels decrease with worsening heart failure, while C5b-9 levels increase. These markers, ficolin-3 and C5b-9, do not correlate with the cause of heart failure.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Heart failure (HF) is a complex clinical syndrome with significant morbidity and mortality.
  • Biomarkers are crucial for assessing cardiac function and disease severity in HF patients.
  • Ficolin-3 and the terminal complement complex C5b-9 are implicated in inflammatory processes.

Purpose of the Study:

  • To investigate the correlation between serum ficolin-3 and C5b-9 levels and cardiac function, as indicated by NT-proBNP, in heart failure patients.
  • To assess the relationship of these markers with the severity of heart failure.
  • To determine if ficolin-3 and C5b-9 levels are associated with the etiology of heart failure.

Main Methods:

  • Sixty heart failure patients (NYHA class II-IV) were enrolled and compared to 20 healthy controls.
  • Serum levels of ficolin-3, C5b-9, and NT-proBNP were measured.
  • Correlation analyses were performed between these markers and heart failure severity and etiology.

Main Results:

  • Serum concentrations of ficolin-3 and C5b-9 were significantly different between heart failure patients and controls.
  • Ficolin-3 showed a negative correlation with NT-proBNP (r=-0.606, p<0.0001), indicating inverse association with heart failure severity.
  • C5b-9 demonstrated a positive correlation with NT-proBNP (r=0.499, p<0.0001), suggesting direct association with heart failure severity.

Conclusions:

  • Serum ficolin-3 is inversely associated with heart failure severity.
  • Serum C5b-9 is positively associated with the severity of cardiac impairment in heart failure.
  • Neither ficolin-3 nor C5b-9 levels showed a significant association with the underlying etiology of heart failure.
Abstract

Keywords:
C5b-9Ficolin-3Heart failure

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