Clinical value of bronchodilator response for diagnosing asthma in steroid-naïve adults

Spirometry and testing for bronchodilator response have been recommended to detect asthma, and a bronchodilator response (BDR) of ≥12% and ≥200 mL has been suggested to confirm asthma. However, the clinical value of bronchodilation tests in newly diagnosed steroid-naïve adult patients with asthma remains unknown. We evaluated the sensitivity of BDR in forced expiratory volume in 1 s (FEV₁) as a diagnostic test for asthma in a real-life cohort of participants in the Seinäjoki Adult Asthma Study. In the diagnostic phase, 369 spirometry tests with bronchodilation were performed for 219 steroid-naïve patients. The fulfilment of each test threshold was assessed. According to the algorithm of the National Institute for Health and Care Excellence, we divided the patients into obstructive (FEV₁/forced vital capacity (FVC) <0.70) and non-obstructive (FEV₁/FVC ≥0.70) groups. Of the overall cohort, 35.6% fulfilled ΔFEV₁ ≥12% and ≥200 mL for the initial FEV₁, 18.3% fulfilled ΔFEV₁ ≥15% and ≥400 mL for the initial FEV₁, and 36.1% fulfilled ΔFEV₁ ≥9% of predicted FEV₁ at least once. One-third (31%) of these steroid-naïve patients was obstructive (pre-bronchodilator FEV₁/FVC <0.7). Of the obstructive patients, 55.9%, 26.5% and 48.5%, respectively, met the same thresholds. In multivariate logistic regression analysis, different thresholds recognised different kinds of asthma patients. In steroid-naïve adult patients, the current BDR threshold (ΔFEV₁ ≥12% and ≥200 mL) has low diagnostic sensitivity (36%) for asthma. In obstructive patients, sensitivity is somewhat higher (56%) but far from optimal. If the first spirometry test with bronchodilation is not diagnostic but asthma is suspected, spirometry should be repeated, and other lung function tests should be used to confirm the diagnosis.