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Updated: Oct 9, 2025

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Inhibiting Calcium Release from Ryanodine Receptors Protects Axons after Spinal Cord Injury

Ben C Orem1,2, Arezoo Rajaee1,3, David P Stirling1,3,2,4

  • 1Kentucky Spinal Cord Injury Research Center, University of Louisville, School of Medicine, Louisville, Kentucky, USA.

Journal of Neurotrauma
|December 16, 2021
PubMed
Summary

Ryanodine receptor (RyR) inhibition shortly after spinal cord injury (SCI) reduces axonal degeneration and improves survival. Early intervention with RyR antagonists shows promise for preventing secondary axonal damage following SCI.

Keywords:
axonal spheroidsintravital microscopyryanodine receptorsecondary degenerationspinal cord injury

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