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[Impacts of different Y chromosome microdeletions on spermatogenesis]
Lai-Qing Zhu1, Xun Wang1, Guo-Hai Sun1
1Laboratory of Andrology, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.
Objective:
To study the semen parameters of the patients with Y chromosome microdeletions and their impacts on the spermatogenesis of the patients.
Methods:
We selected 151 male infertility patients with Y chromosome microdeletions from those diagnosed and treated in our hospital and retrospectively analyzed the influence of their semen parameters on the spermatogenic function.
Results:
Of the 151 cases of Y chromosome microdeletions, AZFc was involved in 102 (66.89%), AZFb in 6 (3.97%), AZFa in 5 (3.31%), AZFa+c in 1 (0.66%), AZFb+c in 6 (3.97%), AZFc+d in 1 (0.66%), AZFb+c+d in 13 (8.61%), AZFa+b+c+d in 12 (7.95%), sY127 in 3 (1.99%), sY134 in 1 (0.66%) and sY86 in 1 (0.66%). Among the total number of the infertility patients, 48 (31.78%) were diagnosed with azoospermia, 74 (49%) with cryptozoospermia, 28 (18.54) with oligoasthenozoospermia and 1 (0.66%) with asthenoteratozoospermia.
Conclusions:
Y chromosome microdeletions may lead to decreased sperm quality, and different types of deletion have different impacts on the spermatogenic function of the patients.
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