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Altered brain activity associated with premature ejaculation improved by electroacupuncture in rats.
Ning Wu1,2, Jian-Huai Chen3, Tong Wang1
1Department of Andrology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.
Sexual Medicine
|September 2, 2024
Summary
Electroacupuncture (EA) treatment for premature ejaculation (PE) in rats reduced ejaculation frequency and extended latency by modulating brain activity. These findings offer insights into PE mechanisms and potential therapeutic strategies.
Area of Science:
- Neuroscience
- Integrative and Complementary Medicine
- Urology
Background:
- Premature ejaculation (PE) is associated with altered brain activity.
- Electroacupuncture (EA) has shown potential in modifying this brain activity for PE treatment.
Purpose of the Study:
- To investigate the central pathological mechanisms of EA in treating PE.
- To explore how EA influences brain activity related to ejaculatory behavior.
Main Methods:
- Male Sprague-Dawley rats were divided into PE and control groups.
- EA was applied to the Zusanli acupoint (ST-36) for 4 weeks.
- Magnetic resonance imaging (MRI), behavioral tests, and plasma norepinephrine levels were assessed.
Main Results:
- EA treatment decreased ejaculation frequency and increased latency in PE rats.
- Norepinephrine levels correlated with ejaculation parameters.
- EA modulated fractional amplitude of low frequency fluctuation (fALFF) and regional homogeneity (ReHo) in specific brain regions.
Conclusions:
- EA at ST-36 may reduce ejaculation frequency and extend latency in PE rats.
- These effects are likely mediated by EA's influence on brain activity.
- Findings may inform new targeted therapies for PE.
