Carbon nitride nanomaterials with application in photothermal and photodynamic therapies

Phototherapies offer treatment of tumors with high spatial selectivity. Photodynamic therapy (PDT) consists in the administration of a photosensitizer (PS) followed by local photoirradiation with light of specific wavelength. The excited states of the PS interact with biomolecules and molecular oxygen producing reactive oxygen species (ROS), which initiate cell death. Photothermal therapy (PTT) employs photothermal agents to harvest the energy from light and convert it into heat to produce a temperature increase of the surrounding environment leading to cell death. Due to their good biocompatibility and unique photophysical properties, carbon-based materials are suitable for application in PDT and PTT. In particular, graphitic carbon nitride (g-C₃N₄), is a low-cost, non-toxic, and environment-friendly material, which is currently being used in the development of new nanomaterials with application in PDT and PTT. This brief review includes recent advances in the development of g-C₃N₄-based nanomaterials specifically designed for achieving red-shifted band gaps with the aim of generating oxygen molecules via water splitting upon red light or NIR irradiation to tackle the hypoxic condition of the tumor area. Nanomaterials designed for theranostics, combining medical imaging applications with PDT and/or PTT treatments are also included. The recent developments of g-C₃N₄-nanomaterials containing lanthanide-based upconversion nanoparticles are also covered. Finally, g-C₃N₄-based nanomaterials employed in microwave induced photodynamic therapy, sonodynamic therapy, and magnetic hyperthermia are considered.