Fabrication of adhesive hydrogels based on poly (acrylic acid) and modified hyaluronic acid

Hydrogel wound dressings with good flexibility and adhesiveness to resist deformation during wound movement are urgently needed in clinical application. In this work, the hydrogels based on poly (acrylic acid) and N-hydroxysuccinimide grafted hyaluronic acid (PAA/HA_-NHS) with good elasticity and adhesiveness were prepared by chemical cross-linking and hydrogen bonding. The elastic and adhesive properties within the PAA hydrogels could reach a balance by adjusting the concentration of potassium persulfate (KPS) and N, N'-methylenebisacrylamide (MBA). Subsequently, HA_-NHS was incorporated into the PAA hydrogel system. The mechanical test revealed that the elongation at break and interfacial toughness of the PAA/HA_-NHS hydrogels could reach 265.79 ± 21.93% and 52.88 ± 3.51 J/m², respectively. In addition, the hydrogels possess a connected porous network and well water absorption ability (with porosity of 51.90 ± 0.11% and swelling ratio in wet state of 122.17 ± 2.78%). In vitro experiment demonstrates that the PAA/HA_-NHS hydrogels exhibit nontoxic and cell in-adhesive properties. The PAA/HA_-NHS hydrogels could cover the wound spots directly, stretch with the skin movement and gently remove from the wound tissue due to the suitable adhesiveness and poor cell adhesion. In conclusion, the PAA/HA_-NHS hydrogels show great application value in the field of wound dressing.