Related Experiment Video
Updated: Oct 9, 2025
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
A promising new predictive factor for detecting bowel resection in childhood intussusception: the
Bailin Chen1,2, Jian Cao1,2, Chengwei Yan3
1Department of Pediatric General Surgery, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Insights
The lymphocyte-C-reactive protein ratio (LCR) can predict the need for intestinal resection in children with intussusception. This inflammatory marker helps identify cases at high risk for necrosis and surgical intervention.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Inflammatory Markers
Background:
- Childhood intussusception poses a risk of intestinal ischemia and necrosis, necessitating early prediction.
- Bowel resection is a critical concern in managing intussusception, highlighting the need for predictive tools.
Purpose of the Study:
- To investigate the predictive value of various inflammatory factor combinations for intestinal necrosis and resection in pediatric intussusception.
- To identify reliable preoperative markers for identifying children requiring intestinal resection.
Main Methods:
- Retrospective review of medical records for pediatric patients with intussusception undergoing surgery.
- Evaluation of preoperative inflammatory markers including neutrophil count, CRP, PLR, NLR, and LCR.
- Utilized receiver operating characteristic (ROC) analysis to assess diagnostic value.
Main Results:
- 40.9% of 115 intussusception patients required intestinal resection.
- Significantly higher neutrophil count, CRP, PLR, NLR, and LCR in patients with resection.
- The lymphocyte-C-reactive protein ratio (LCR) showed the highest correlation with intestinal resection (sensitivity 0.82, specificity 0.80).
Conclusions:
- Preoperative LCR levels are a valuable marker for predicting intestinal resection due to necrosis in intussusception.
- LCR demonstrates high sensitivity and specificity in diagnosing strangulation requiring resection.
Background:
The most critical concern for the management of childhood intussusception is bowel resection due to intestinal ischemia and necrosis. The early prediction of this problem is of great importance. We investigated the value of various combinations of inflammatory factors to predict intestinal necrosis and resection.
Methods:
We retrospectively reviewed the medical records of pediatric patients with intussusception who underwent surgical management. During the research period, 47 patients who underwent intestinal resection due to intestinal necrosis and 68 patients who did not undergo intestinal resection were enrolled. We evaluated the diagnostic value of various combinations of inflammatory markers from preoperative laboratory analyses using the receiver operating characteristic (ROC) method.
Results:
In the current cohort, 115 patients underwent operations for intussusception; among them, 47 patients (40.9%) underwent intestinal resections. In the patients with intestinal resection, the neutrophil count(p = 0.013), CRP level(p = 0.002), platelet-lymphocyte ratio (PLR, p = 0.008), NLR (neutrophil-lymphocyte ratio, p = 0.026), and LCR (lymphocyte-CRP ratio, p < 0.001) values were significantly higher than those in the patients without any resection. The receiver operating characteristic (ROC) analysis results showed that the combination of lymphocytic count along with C-reactive protein levels (LCR) demonstrated the highest correlation with intestinal resection due to intussusception compared with other parameters in the patients, with a sensitivity of 0.82 (0.73-0.86) and specificity of 0.80 (0.57-0.94) for the diagnosis of strangulation.
Conclusion:
The preoperative LCR level is a useful marker to predict the need for intestinal resection due to intestinal necrosis in patients with intussusception.
More Related Videos
05:45Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD: