Related Experiment Video
Updated: Oct 9, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Does non-surgical periodontal treatment influence on rheumatoid arthritis? A systematic review and meta-analysis
Cleber Davi Del Rei Daltro Rosa1, Jéssica Marcela de Luna Gomes1, Sandra Lúcia Dantas de Moraes2
1Department of Dental Materials and Prosthodontics, Dentistry School, UNESP - São Paulo State University, R: José Bonifácio, 1193, Vila Mendonça, Araçatuba, São Paulo, Brazil.
Objective:
The objective of this systematic review was to evaluate the efficacy of non-surgical periodontal therapy on rheumatoid arthritis activity.
Material And Methods:
Articles published until April 2019 were electronically searched and screened using PubMed / MEDLINE, Scopus, and Cochrane databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). This study was recorded in the international PROSPERO database (CRD42019132205). The PICO question (population, intervention, comparison, results) was: in adult patients with rheumatoid arthritis and periodontitis (P), does non-surgical periodontal treatment (I), as compared to no treatment (C), provides better outcomes in rheumatoid arthritis activity (O).
Results:
After searching the databases, seven articles were selected for qualitative and five for quantitative analysis. The total number of participants included was 292, with an average age of 50.5 years. All patients had rheumatoid arthritis and periodontal disease. Non-surgical periodontal treatment significantly reduced Disease Activity Score 28 (P = 0.004; I2 = 92%) and erythrocyte sedimentation rate (P = 0.01; I2 = 78%), but with no significant effect on C-reactive protein (P = 0.34; I2 = 92%).
Conclusions:
It can be concluded that non-surgical periodontal treatment can benefit patients with rheumatoid arthritis.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Rheumatic Heart Disease III: Medical Management
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The JAK-STAT Signaling Pathway
Rheumatic Heart Disease I: Introduction

