Isolated Superior Mesenteric Artery Dissection After Methamphetamine Use: A Rare Adverse Effect

Area of Science:

• Cardiology
• Toxicology
• Gastroenterology

Background:

• Methamphetamine is a widely abused stimulant drug.
• Cardiovascular complications are a leading cause of mortality in methamphetamine users.
• Sympathomimetic agents like methamphetamine affect neurotransmitter reuptake.

Observation:

• A 41-year-old male presented with acute epigastric abdominal pain radiating to the back.
• Physical examination revealed agitation, diaphoresis, dilated pupils, tachycardia, and hypertension.
• Toxicology screening confirmed methamphetamine use, which preceded the onset of pain.

Findings:

• The patient was diagnosed with superior mesenteric artery dissection, a rare condition.
• Treatment included fluid resuscitation, analgesics, antihypertensives, and anticoagulants.
• The patient showed significant improvement and complete pain resolution within 48 hours.

Implications:

• This case highlights the critical need to consider cardiovascular adverse effects of methamphetamine use.
• Physicians should be aware of rare complications such as mesenteric artery dissection in patients with methamphetamine exposure.
• Prompt diagnosis and management of methamphetamine-induced cardiovascular events are essential.