Related Experiment Video
Updated: Oct 9, 2025
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Predictors of persistent inflammation in children with familial Mediterranean fever
Deniz Gezgin Yıldırım1, Pelin Esmeray Senol1, Oğuz Söylemezoğlu1
1Department of Paediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Insights
Persistent inflammation in familial Mediterranean fever (FMF) is predicted by M694V homozygosity, colchicine resistance, and specific clinical features. Identifying these predictors aids in early detection and better management of FMF complications.
Area of Science:
- Pediatric Rheumatology
- Genetics
- Inflammatory Diseases
Background:
- Familial Mediterranean fever (FMF) is characterized by persistent inflammation, potentially leading to chronic complications.
- Identifying predictors of persistent inflammation is crucial for proactive management in pediatric FMF patients.
Purpose of the Study:
- To investigate the predictors of persistent inflammation in children diagnosed with familial Mediterranean fever (FMF).
Main Methods:
- Retrospective analysis of medical charts from 1077 pediatric FMF patients.
- Patients were categorized into groups with and without subclinical inflammation based on specific criteria.
Main Results:
- 133 (12%) patients exhibited persistent inflammation.
- Independent predictors included M694V homozygosity, colchicine resistance, family history, erysipelas-like erythema, leg pain, arthritis, chest pain, inflammatory comorbidities, early onset, high PRAS score, and long attack duration.
- Gender, abdominal pain, fever, and attack frequency were not significant predictors.
Conclusions:
- M694V homozygosity, colchicine resistance, family history, and specific clinical manifestations are key predictors of persistent inflammation in FMF.
- These findings can assist clinicians in identifying children at risk for subclinical inflammation.
- Early identification of these predictors may improve disease management and prevent chronic complications in FMF.
Objectives:
Persistent inflammation is an insidious feature of familial Mediterranean fever (FMF) that may cause chronic complications. This study aimed to investigate the predictors of persistent inflammation in children with FMF.
Methods:
The medical charts of 1077 paediatric FMF patients were retrospectively collected. The patients were divided into two groups: with and without subclinical inflammation.
Results:
A total of 133 (12%) patients had persistent inflammation. M694V homozygosity, colchicine resistance, positive family history for FMF, erysipelas-like erythema, leg pain, arthritis, chest pain, inflammatory comorbidities, early disease onset, high PRAS score, and long attack duration were established as independent predictors of persistent inflammation (P < .001, P < .001, P < .001, P < .001, P = 0.006, P < .001, P < .001, P = .014, P < .001, P < .001, and P < .001, respectively). However, gender, abdominal pain, fever, and attack frequency were not found to be independent risk factors for predicting persistent inflammation (P = .412, P = .531, P = .451, and P = .693, respectively).
Conclusions:
M694V homozygosity, colchicine resistance, positive family history, erysipelas-like erythema, leg pain, arthritis, chest pain, inflammatory comorbidities, early disease onset, high activity score, and long attack duration may be predictors of persistent inflammation in FMF. These predictors may help clinicians suspect the occurrence of subclinical inflammation and should aid in better disease management in FMF.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...