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Paediatric neuro-Behçet's disease: multi-centre observational study.

Zahide Ekici Tekin1,2, Merve C Polat2, Yağmur Bayındır3

  • 1Department of Pediatric Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara Bilkent City Hospital, Ankara, Turkey.

Rheumatology (Oxford, England)
|April 13, 2026
PubMed
Summary

Neuro-Behçet's disease (NBD) predominantly affects children with non-parenchymal involvement. Early MRI confirmation and aggressive immunosuppressive therapy lead to significant clinical improvement in pediatric NBD patients.

Keywords:
childrenneuro-Behçet’s diseaseneuroimagingprognosistreatment

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Area of Science:

  • Pediatric Rheumatology
  • Neurology
  • Immunology

Background:

  • Behçet's disease (BD) is a multisystemic inflammatory condition.
  • Neurologic involvement (NBD) significantly impacts pediatric patients.
  • Understanding NBD's pediatric manifestations is crucial for prognosis.

Purpose of the Study:

  • To elucidate neurologic manifestations in a large pediatric BD population.
  • To describe outcomes and prognosis of pediatric NBD.
  • To identify key features differentiating NBD subgroups.

Main Methods:

  • Retrospective multicenter study of 75 pediatric NBD patients.
  • Review of demographic, clinical, neuroimaging, and treatment data.
  • Analysis of disability conditions and follow-up outcomes.

Main Results:

  • 69.3% presented with neurologic symptoms at diagnosis; 30.7% later.
  • Non-parenchymal NBD (74.7%) was most common, often with headache.
  • Parenchymal NBD showed more paresis, sensory loss, and mood issues. Vascular lesions (73.3%) were frequent.

Conclusions:

  • Pediatric NBD is a significant rheumatologic concern, with non-parenchymal forms predominating.
  • MRI is essential for NBD diagnosis and classification in children.
  • Early, aggressive immunosuppressive therapy improves clinical outcomes.