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A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth
Yuting Wen1, Nana Nyarko Mensah1,2, Xia Song1
1Department of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, 119276, Singapore. jun-li@nus.edu.sg.
Abstract:
A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface was fabricated through surface modification using β-cyclodextrin-based host-guest chemistry. Interestingly, the hydrogel surface not only selectively captured specific cancer cells, but also grew the cells into multicellular spheroids. The spheroids could be released without damaging the cell viability through replacing the host moieties on the scaffold, and the released spheroids showed no changes in size or morphology.
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