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Systematic review of associations between HLA and renal function
Marcus Lowe1,2, Steven Jervis1,2, Antony Payton3
1Transplantation Laboratory, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.
International Journal of Immunogenetics
|December 17, 2021
Summary
Human leukocyte antigen (HLA) types show varied associations with kidney function, with many findings lacking consensus. Further research is needed to clarify reliable HLA associations with renal dysfunction and its progression.
Area of Science:
- Immunogenetics
- Nephrology
- Human Genetics
Background:
- Kidney dysfunction is a significant global health issue.
- Previous studies suggest links between human leukocyte antigens (HLA) and renal function.
Purpose of the Study:
- To systematically review and appraise published studies on HLA and renal function associations.
- To identify and summarize all reported associations between HLA types and kidney function.
Main Methods:
- A comprehensive literature search was conducted across Medline, Embase, and Cochrane Central Register.
- Keywords included HLA, renal failure, and genetic association.
- 35 out of 245 identified papers were included in the final analysis.
Main Results:
- 95 HLA types and 14 haplotypes were associated with altered renal function.
- Replicated findings indicated 16 HLA types were protective and 15 were associated with reduced renal function.
- 20 HLA types showed conflicting associations (both increased and decreased risk) across studies.
Conclusions:
- There is a lack of consensus regarding specific HLA types' effects on renal function.
- Potential influencing factors include ethnicity and the primary cause of end-stage renal disease (ESRD).
- Methodological limitations in studies necessitate further research to validate findings.
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