Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.3K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.3K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

2.0K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures.

Biogerontology·2026
Same author

Gut Microbiome Signatures Distinguish Susceptibility from Disease Development in Type 2 Diabetes.

International journal of molecular sciences·2026
Same author

Parkin overexpression modulates gut-microbiota composition during aging in <i>Drosophila melanogaster</i>.

Frontiers in microbiology·2025
Same author

Mesenchymal stem cells and their derivatives as potential longevity-promoting tools.

Biogerontology·2025
Same author

Severe Intra- and Post-Operative Lactic Acidosis in a Patient Who Underwent Robotic Thoracoscopic Surgery.

Biomedicines·2025
Same author

Stem cells in ageing and longevity: a new section in Biogerontology.

Biogerontology·2025
Same journal

Short-term responsiveness of DNA methylation-based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing <i>Bifidobacterium longum</i> BB536: an exploratory randomized controlled trial.

Aging·2026
Same journal

Hormonal dimorphism in sarcopenia disease.

Aging·2026
Same journal

The multifaceted inducers of cellular senescence.

Aging·2026
Same journal

Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.

Aging·2026
Same journal

Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.

Aging·2026
Same journal

The love and hate relationship between cellular senescence and stemness.

Aging·2026
See all related articles

Related Experiment Video

Updated: Oct 9, 2025

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
08:56

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

6.8K

Small molecules for cell reprogramming: a systems biology analysis.

Anna Knyazer1, Gabriela Bunu2, Dmitri Toren2

  • 1The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Aging
|December 17, 2021
PubMed
Summary
This summary is machine-generated.

Small Molecules (SMs) can reprogram cells, offering a potential solution for aging and rejuvenation. Analysis reveals SMs target pathways crucial for cell function, longevity, and age-related diseases.

Keywords:
cell reprogrammingchemical-protein interactionschemically-induced pluripotencylongevity pathwaysprotein-protein interaction networks

More Related Videos

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.6K
Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
09:29

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

7.6K

Related Experiment Videos

Last Updated: Oct 9, 2025

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
08:56

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

6.8K
A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.6K
Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
09:29

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

7.6K

Area of Science:

  • Cellular biology
  • Molecular biology
  • Gerontology

Background:

  • Somatic stem cells lose regenerative capacity over time due to aging.
  • Small Molecules (SMs) are low molecular weight compounds that can induce or enhance cell reprogramming.
  • SMs offer potential advantages over introducing stemness-related transcription factors.

Purpose of the Study:

  • To systematically analyze Small Molecules (SMs) and their potential gene targets for cell reprogramming.
  • To investigate the functional categories and network organization of SM targets.
  • To explore the connection between SM targets, aging, and longevity.

Main Methods:

  • Data mining and curation to identify 92 SMs and their targets.
  • Functional enrichment analysis of SM targets.
  • Network analysis of protein-protein interactions among SM targets.

Main Results:

  • SM targets fall into three categories: epigenetics, cell signaling, and metabolic switchers, all required for reprogramming.
  • Enriched pathways of SM targets are significantly related to aging, longevity, and age-related diseases.
  • SM targets form interconnected protein-protein networks with scale-free topology, suggesting cooperative action and robustness.

Conclusions:

  • SMs hold promise for cell reprogramming, rejuvenation, and life span extension.
  • Understanding SMs' relationship with longevity regulators is key to developing optimal reprogramming cocktails.
  • The network organization of SM targets highlights the importance of cooperative action for effective cell reprogramming.