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Anticancer effects of acteoside: Mechanistic insights and therapeutic status

Rasel Ahmed Khan¹, Rajib Hossain², Pranta Roy³

¹Pharmacy Discipline, Khulna University, Khulna, 9280, Bangladesh.

European Journal of Pharmacology

|December 17, 2021

Abstract:

Cancer, the uncontrolled proliferation and metastasis of abnormal cells, is a major public health issue worldwide. To date, several natural compounds have been reported with their efficacy in the treatment of different types of cancer. Chemotherapeutic agents are used in cancer treatment and prevention, among other aspects. Acteoside is a phenylethanoid glycoside, first isolated from Verbascum sinuatum, which has demonstrated multiple effects, including antioxidant, anti-epileptic, neuroprotective, anti-inflammatory, antifungal, antihypertensive, and anti-leishmanial properties. This review gathered, analyzed, and summarized the literature on acteoside and its anticancer properties. All the available information about this compound and its role in different types of cancer was collected using different scientific search engines, including PubMed, Scopus, Springer Link, Wiley Online, Web of Science, Scifinder, ScienceDirect, and Google Scholar. Acteoside is found in a variety of plants and has been shown to have anticancer activity in many experimental models through oxidative stress, apoptosis, anti-angiogenesis, anti-invasion, anti-metastasis, synergism with other agents, and anti-proliferative effects through modulation of several pathways. In conclusion, acteoside exhibited potent anticancer activity against different cancer cell lines through modulating several cancer signaling pathways in different non- and pre-clinical experimental models and thus could be a strong candidate for further clinical studies.

Insights

Acteoside, a natural compound, shows significant anticancer properties by impacting cancer cell proliferation, metastasis, and signaling pathways. Further clinical studies are warranted to explore its therapeutic potential in cancer treatment.

Area of Science:

Pharmacology
Natural Product Chemistry
Oncology

Background:

Cancer remains a critical global health challenge, necessitating novel therapeutic strategies.
Natural compounds are increasingly investigated for their potential in cancer treatment.
Acteoside, a phenylethanoid glycoside, possesses diverse biological activities.

Purpose of the Study:

To review and synthesize existing literature on the anticancer properties of acteoside.
To analyze the mechanisms by which acteoside exerts its anti-cancer effects.
To evaluate acteoside's potential as a candidate for cancer therapy.

Main Methods:

Comprehensive literature search using major scientific databases (PubMed, Scopus, Web of Science, etc.).
Analysis and summarization of studies investigating acteoside's effects on various cancer models.
Identification of key molecular pathways modulated by acteoside.

Main Results:

Acteoside demonstrates anticancer activity across multiple experimental cancer models.
Mechanisms include induction of oxidative stress, apoptosis, and inhibition of angiogenesis, invasion, and metastasis.
Acteoside exhibits anti-proliferative effects through modulation of cancer signaling pathways.
Synergistic effects with other anti-cancer agents have been observed.

Conclusions:

Acteoside displays potent anticancer activity against diverse cancer cell lines.
Its efficacy is mediated by the modulation of critical cancer signaling pathways.
Acteoside represents a promising candidate for further preclinical and clinical investigation in cancer therapy.

Read full analysis

Keywords:

Acteoside Angiogenesis Cancer Cell cycle arrest Metastasis Synergistic effect

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