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Marine collagen scaffolds in tissue engineering.

Shaoqiong Liu1, Chau-Sang Lau2, Kun Liang3

  • 1School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457, Singapore.

Current Opinion in Biotechnology
|December 17, 2021
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Summary

Marine collagen offers a safer, sustainable alternative to traditional sources for medical use. Fabrication methods are key to optimizing marine collagen constructs for tissue regeneration applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Marine Biotechnology

Background:

  • Collagen is a primary human extracellular matrix component.
  • Bovine and porcine collagen carry risks of pathogen transfer.
  • Marine waste represents a significant, underutilized resource.

Purpose of the Study:

  • To review advances in designing and fabricating marine collagen constructs.
  • To highlight marine collagen's potential in medical applications.
  • To address challenges and opportunities in marine collagen utilization.

Main Methods:

  • Literature review of marine collagen extraction and fabrication techniques.
  • Analysis of marine collagen properties and advantages.
  • Exploration of medical applications in tissue regeneration.

Main Results:

  • Marine collagen offers lower zoonotic and immunological risks.
  • Extraction from marine waste is economically viable and sustainable.
  • Fabrication methods significantly influence construct properties.

Conclusions:

  • Marine collagen is a promising biomaterial for medical applications.
  • Further research into fabrication is needed to optimize performance.
  • Marine collagen holds potential for skin, bone, and cartilage regeneration.