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Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Nanoparticles for generating antigen-specific T cells for immunotherapy.

Savannah E Est-Witte¹, Natalie K Livingston², Mary O Omotoso³

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Translational Tissue Engineering Center, USA, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

Seminars in Immunology

|December 19, 2021

Summary

Nanoparticles offer a versatile platform to enhance T cell therapies, overcoming limitations of current treatments. This approach improves antigen-specific T cell responses for immunotherapy applications.

Keywords:

Bioengineering Cell therapy Immunoengineering Immunotherapy Nanoparticle T cell

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Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Area of Science:

Immunology
Nanotechnology
Biotechnology

Background:

T cell therapy is a promising immunotherapy but faces challenges like cost and patient variability.
Current T cell therapies include adoptive cell transfer and vaccines, which have limitations.

Purpose of the Study:

To review the applications of nanoparticles in antigen-specific T cell therapy.
To highlight how nanoparticles can improve T cell targeting, organ targeting, and internalization.
To discuss nanoparticles as vaccines, artificial Antigen Presenting Cells (aAPCs), and drug delivery vehicles.

Main Methods:

Review of existing literature on nanoparticle applications in T cell therapy.
Focus on nanoparticle roles in antigen presentation, T cell activation, and T cell maintenance.
Categorization of nanoparticle applications into vaccines, aAPCs, and drug delivery.

Main Results:

Nanoparticles provide a modular platform to enhance T cell therapy efficacy.
Nanoparticle properties can be tailored for improved targeting and cellular uptake.
Nanoparticles can activate endogenous antigen-presenting cells (APCs) or directly activate T cells.

Conclusions:

Nanoparticles represent a significant advancement in antigen-specific T cell therapy.
They offer solutions to limitations of current T cell-based treatments.
Nanoparticles can be utilized as vaccines, aAPCs, or drug delivery systems to support T cell functions.