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Isolation of Human Islets from Partially Pancreatectomized Patients

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EVALUATION OF PARAMETERS OF ACTUAL TYPICAL PATHOGENETIC SYNDROMES IN COMORBIDITY OF TYPE 2 DIABETES MELLITUS AND

Olena V Redkva¹, Liliya S Babinets¹, Iryna M Halabitska¹

¹HORBACHEVSKY NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)

|December 19, 2021

Abstract

Objective:

The aim: To assess the state of typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) in the comorbidity of type 2 diabetes mellitus (DM2) and chronic pancreatitis (CP).

Patients And Methods:

Materials and methods: We examined 137 patients (112 patients with comorbidity of CP and DM2 and 25 patients with isolated CP. Typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) were determined.

Results:

Results: It was proved that patients with CP even in the remission phase of the active course of EI and LPO, which was significantly more significant in comorbidity with DM2. Statistically significant more significant changes in the parameters of antioxidant protection in the comorbidity of CP and DM2 in relation to those in isolated CP.

Conclusion:

Conclusions: Treatment of CP and DM2 is a difficult task and should take into account the impact on the studied common typical pathogenetic syndromes - inflammation, endotoxicosis, lipid peroxidation, and enzyme and non-enzymatic antioxidant protection - to address short-term and prevent long-term complications.

Keywords:

chronic pancreatitis type 2 diabetes mellitus

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