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Updated: Oct 9, 2025
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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COVID-19 in patients with glomerular disease
Tabitha Turner-Stokes1,2, Helena Edwards1,2, Liz Lightstone1,2
1Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London.
Current Opinion in Nephrology and Hypertension
|December 19, 2021
Summary
Patients with glomerular disease face higher COVID-19 mortality risks. Vaccination is crucial, though immunosuppression may reduce vaccine effectiveness, necessitating further research into enhanced vaccination strategies for these vulnerable individuals.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Managing glomerular disease during the COVID-19 pandemic presents a balance between infection risk from immunosuppression and controlling severe kidney disease.
- Patients with glomerular diseases are at increased risk for severe COVID-19 outcomes.
Purpose of the Study:
- To review COVID-19 and the effectiveness of SARS-CoV-2 vaccination in patients with glomerular disease.
- To assess the challenges and strategies for managing glomerular disease patients amidst the pandemic.
Main Methods:
- Review of registry data and case reports concerning COVID-19 outcomes in glomerular disease patients.
- Analysis of the impact of immunosuppressive therapies (glucocorticoids, rituximab) on COVID-19 outcomes and vaccine response.
Main Results:
- COVID-19 mortality is higher in glomerular disease patients compared to the general population.
- Prior glucocorticoid use is linked to worse COVID-19 outcomes.
- Rituximab may attenuate serological responses to SARS-CoV-2 infection and vaccination, but clinical outcomes remain unclear.
- Reported disease flares post-vaccination are rare, with unproven causality.
Conclusions:
- Vaccination is essential for mitigating severe COVID-19 risk in glomerular disease patients.
- The attenuated immune response in immunosuppressed patients warrants investigation into additional vaccine doses and boosters.
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