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Rewritable Surface on a Plastic Substrate Using Fluorous Affinity.

Takane Tsuchii1, Kazuki Kaneko1, Kenta Morita1

  • 1Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe 657-8501, Japan.

ACS Applied Materials & Interfaces
|December 20, 2021
PubMed
Summary

This study demonstrates rewritable surface functionalization using fluorous affinity, enabling the immobilization and patterning of molecules on plastic surfaces. This novel approach utilizes fluorous-fluorous interactions for adaptable surface modification and biomolecule patterning.

Keywords:
erasable surface functionfluoropolymermicropatterningsurface immobilizationsurface segregation

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Area of Science:

  • Materials Science
  • Surface Chemistry
  • Organic Chemistry

Background:

  • Fluorous chemistry offers unique properties distinct from nonfluorinated compounds.
  • Applications of fluorous-fluorous interactions (fluorophilicity) are underexplored due to their absence in nature.
  • Developing novel surface functionalization methods is crucial for advanced material applications.

Purpose of the Study:

  • To develop a rewritable surface functionalization method for plastic substrates utilizing fluorous affinity.
  • To investigate the immobilization and quantitative analysis of fluorous-tagged molecules on functionalized surfaces.
  • To demonstrate the potential for micropatterning biomolecules on plastic surfaces.

Main Methods:

  • Plastic substrates were dip-coated with methacrylate-based fluoropolymers to create fluorous surfaces.
  • Fluorous-tagged small molecules (perfluoroalkyl amines) were immobilized via fluorous-fluorous interactions.
  • Surface-bound amino groups were quantified using a reactive fluorophore, and immobilization was optimized by varying polymer and amine structures.

Main Results:

  • Effective immobilization of perfluoroalkyl amines on fluorous surfaces was achieved, introducing reactive amino groups.
  • Quantitative analysis confirmed the accessibility of immobilized amino groups for subsequent reactions.
  • Optimal immobilization was observed with a fluoropolymer containing -C8F17 and an Rf-amine with two -C6F13 chains.
  • Immobilized molecules were easily removed and re-immobilized, demonstrating rewritability.
  • Rewritable micropatterning of an Rf-tagged biomolecule was successfully achieved via microcontact printing.

Conclusions:

  • Fluorous affinity provides a robust platform for rewritable surface functionalization of plastic substrates.
  • The developed method allows for quantitative control and patterning of fluorous-tagged molecules, including biomolecules.
  • This approach opens new avenues for designing adaptable surfaces with tailored functionalities for various applications.