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Therapeutic Options for Coronavirus Disease 2019 (COVID-19): Where Are We Now?

Esther Y Golnabi1, James M Sanders1, Meagan L Johns1

  • 1Department of Pharmacy, University of Texas Southwestern Medical Center, Dallas, US.

Current Infectious Disease Reports
|December 20, 2021
PubMed
Abstract

Insights

This review summarizes clinical evidence for coronavirus disease 2019 (COVID-19) treatments. It highlights findings from key studies to guide clinicians on effective COVID-19 therapies and management strategies.

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Pharmacology

Background:

  • The COVID-19 pandemic has spurred extensive research into various treatment strategies.
  • Understanding the evolving landscape of COVID-19 therapies is crucial for effective patient management.
  • Clinical observations emphasize the importance of treatment timing in relation to COVID-19 disease phases.

Purpose of the Study:

  • To review and synthesize clinical evidence on recommended drugs and management strategies for COVID-19.
  • To provide clinicians with an updated overview of therapeutic options for COVID-19.
  • To critically appraise the voluminous data produced during the pandemic.

Main Methods:

  • Systematic review of key interventional treatment trials for COVID-19.
  • Analysis of observational, retrospective, and randomized controlled studies.
  • Evaluation of evidence from large, randomized, or adaptive platform trials.

Main Results:

  • Large-scale trials have been most informative in guiding recommended COVID-19 treatments.
  • Antimicrobial stewardship is vital for appropriate use of COVID-19 therapies.
  • Many COVID-19 therapies are still under investigation for optimal use.

Conclusions:

  • Clinicians must stay updated with rapidly evolving COVID-19 treatment guidelines.
  • Referencing continuously updated national and international guidelines is recommended.
  • Current recommendations represent the state of knowledge, with ongoing research defining optimal COVID-19 treatment.
Keywords:
AnticoagulationAntimicrobial stewardshipAntiviralsCOVID-19ImmunomodulatorsSARS-CoV-2

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