RARE MALIGNANT FEMALE ADNEXAL TUMOR OF WOLFFIAN ORIGIN (FATWO) WITH MULTIPLE RELAPSES AND CHEMOTHERAPY REGIMENS

Area of Science:

• Gynecologic Oncology
• Pathology of rare tumors

Background:

• Female adnexal tumors of probable Wolffian origin (FATWO) are rare borderline ovarian tumors with low malignant potential.
• Malignant FATWO cases are exceptionally rare, with only 15 reported, and just 5 with recurrence.

Observation:

• Presents the 6th reported case of malignant recurrent FATWO.
• Includes a stage III case with multiple recurrences after a 6-year disease-free interval.
• Reviews literature comparing therapeutic strategies for recurrent malignant FATWO.

Findings:

• The presented case achieved the longest survival reported in the literature.
• This patient underwent extensive surgical procedures and multiple chemotherapy regimens.
• Literature review highlights varied therapeutic approaches and outcomes for recurrent malignant FATWO.

Implications:

• Provides insights into managing rare recurrent malignant FATWO.
• Offers practical therapeutic strategies for clinicians based on available treatments.
• Contributes to understanding the long-term management of this rare ovarian malignancy.