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Related Concept Videos

Selectins01:25

Selectins

3.5K
Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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Updated: Oct 9, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Targeting Selectins Mediated Biological Activities With Multivalent Probes.

Deepak Ganesh1, Prashant Jain1, Chethan Devanur Shanthamurthy1

  • 1Indian Institute of Science Education and Research, Pune, India.

Frontiers in Chemistry
|December 20, 2021
PubMed
Summary

Selectins, key proteins in inflammation and disease, bind to specific sugar structures. Multivalent probes targeting these selectin ligands offer new strategies for treating inflammatory diseases and cancer.

Keywords:
cancerdrug deliveryimagingnanoparticlesselectins

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Area of Science:

  • Biochemistry
  • Immunology
  • Molecular Biology

Background:

  • Selectins are type-I transmembrane glycoproteins found on platelets, endothelial cells, and leukocytes.
  • They mediate leukocyte rolling and recruitment to inflammatory sites by binding to cell surface glycoproteins and extracellular matrix ligands.
  • Selectins are implicated in inflammatory diseases, thrombosis, cardiovascular disorders, and tumor metastasis.

Purpose of the Study:

  • To review selectin-mediated diseases.
  • To summarize recent advancements in multivalent probes for targeting selectins.

Main Methods:

  • Literature review of selectin function and associated diseases.
  • Analysis of studies on multivalent probes functionalized with selectin ligands.

Main Results:

  • Fucosylated and sialylated glycans (e.g., sialyl Lewisx, sialyl Lewisa, heparan sulfate) are primary selectin ligands.
  • Functionalizing multivalent probes (nanoparticles, liposomes, polymers) with these ligands inhibits selectin activity and enables inflammation imaging.
  • Selectin targeting is relevant for thrombosis, cancer, and inflammatory conditions.

Conclusions:

  • Selectins are crucial in disease pathogenesis, making them therapeutic targets.
  • Multivalent probes offer a promising approach for inhibiting selectin function and for diagnostic imaging in inflammatory diseases and cancer.