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Updated: Oct 9, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Fourier computed tomographic imaging of two dimensional fluorescent objects
Patrick A Stockton1, Keith A Wernsing1, Jeffrey J Field1,2,3
1Department of Electrical and Computer Engineering, Colorado State University, Ft. Collins, Colorado 80523, USA.
Abstract:
We introduce a new form of tomographic imaging that is particularly advantageous for a new class of super-resolution optical imaging methods. Our tomographic method, Fourier Computed Tomography (FCT), operates in a conjugate domain relative to conventional computed tomography techniques. FCT is the first optical tomography method that records complex projections of the object spatial frequency distribution. From these spatial frequency projections, the spatial slice theorem is derived, which is used to build a tomographic imaging reconstruction algorithm. FCT enables enhancement of spatial frequency support along a single spatial direction to be isotropic in the entire transverse spatial frequency domain.
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