A Novel Imidazolinone Derivative with 5-Arylidene and 2-Substituted Mercapto Group as Potent Anti-Hepatitis C Virus
Ying Kong1, Chongyang Mao2, Shu Li1
1State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan Hubei, 430071, P. R. China.
Chemistry & Biodiversity
|December 20, 2021
Abstract:
Here six novel imidazolinone derivatives have been synthesized and the compound 4b containing 5-para-methoxy-phenylidene and 2-thioalkylation terminal substitution with 3'-cyano-2',6'-dimethylphenyl showed the best anti-HCV activity and the lowest cytotoxicity. Selectivity index (SI=CC50 /IC50 ) for the 4b was determined as 36, indicating that compound 4b was highly selective towards HCV.
Keywords:
anti-HCV compoundsantiviral activitydirect-actingimidazolinone with 5-arylidene and 2-substituted mercapto group

