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Eosinophils and melanoma: Implications for immunotherapy

India Robinson1, Gabriella Santa Lucia1, Andraia Li1

  • 1Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Pigment Cell & Melanoma Research
|December 20, 2021
PubMed

Insights

Eosinophils may improve survival in advanced melanoma patients treated with immune checkpoint blockers (ICB). Further research into eosinophil function could enhance ICB therapy and predict patient response.

Area of Science:

  • Oncology
  • Immunology
  • Hematology

Background:

  • Advanced melanoma survival is improved by immune checkpoint blockers (ICB).
  • ICBs cause significant side effects across multiple organ systems.
  • Current biomarkers for ICB tolerance are limited by heterogeneity and clinical translation challenges.

Purpose of the Study:

  • To review eosinophil functionality and their role in melanoma.
  • To discuss how eosinophils may influence response to ICBs.
  • To explore the clinical implications of eosinophils in advanced melanoma treatment.

Main Methods:

  • Literature review of eosinophil function in cancer.
  • Analysis of observational studies linking eosinophils to melanoma survival.
  • Discussion of potential mechanisms of eosinophil-mediated ICB response.

Main Results:

  • Eosinophil counts and eosinophil cationic protein levels correlate with prolonged survival in advanced melanoma.
  • Eosinophils may play a complex role in modulating tumor immunity and treatment response.
  • Emerging evidence suggests eosinophils as potential predictive biomarkers for ICB therapy.

Conclusions:

  • Eosinophils represent a promising area for understanding and improving ICB efficacy in melanoma.
  • Further investigation into eosinophil mechanisms is crucial for clinical application.
  • Targeting or leveraging eosinophils could optimize advanced melanoma treatment strategies.
Keywords:
eosinophilsimmunotherapymelanomaprognostic markers

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