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Updated: Oct 9, 2025

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Radical Reactions of Ynamides

Tong-De Tan1, Ze-Shu Wang1, Peng-Cheng Qian2

  • 1Key Laboratory for Chemical Biology of Fujian Province & State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

Small Methods
|December 20, 2021
PubMed
Summary

This review summarizes radical reactions involving ynamides (alkynes tethered to an amide group), focusing on their reactivity at the alpha and beta positions. It highlights advances in selectivity, scope, and mechanisms for these underutilized synthetic transformations.

Keywords:
cyclizationsheterocyclesradical reactionsregioselectivityynamides

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