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Updated: Oct 9, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
[Extracellular vesicles and metabolic diseases: Dangerous liaisons]
Alexia Blandin1, Soazig Le Lay1
1Université de Nantes, CNRS, Inserm, Institut du thorax, F-44000 Nantes, France - Univ Angers, SFR Interactions cellulaires et applications thérapeutiques (ICAT), F-49000 Angers, France.
Abstract:
Extracellular vesicles (EVs) correspond to a heterogeneous set of membrane nanovesicles secreted in the extracellular medium and circulating in the various fluids of the body. These EVs convey biological material (proteins, lipids, nucleic acids) that they can transfer to target cells/tissues thus modulating their response and/or phenotype. The metabolic dysfunctions characterizing metabolic diseases associated with obesity are associated with changes in circulating EV concentrations as well as alterations in their content. The growing interest in EVs as new vectors of intercellular communication has led to question about their role in the development of metabolic complications. In this review, we will discuss the literature on circulating EVs as potential markers of metabolic diseases and then detail inter-organ dialogue based on this EV trafficking underlying the development of related obesity. Finally, we will discuss future avenues of research that will help to better understand the link between EVs and metabolic diseases.
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