Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished!
Louise H Wong1, Andrea Martello1, Emily R Eden1
1University College London Institute of Ophthalmology, London, UK.
The Journal of Cell Biology
|December 20, 2021
Abstract:
Heterogeneity in endosomal membrane phospholipid content is emerging as a regulator of endocytic trafficking pathways. Kawasaki et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202103141) demonstrate exchange of endosomal PI4P for PS by ORP10 at ER-endosome contact sites, with the consequent recruitment of endosomal fission factors.
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