Long non-coding RNA XIST: a novel oncogene in multiple cancers
Jun Yang1, Manlong Qi2, Xiang Fei3
1Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Molecular Medicine (Cambridge, Mass.)
|December 21, 2021
Summary
The long non-coding RNA XIST acts as an oncogene in many human tumors, influencing cancer development and progression. This review details XIST
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is crucial in mammalian gene regulation.
- Aberrant XIST expression is observed in various human cancers, often promoting tumor growth.
Purpose of the Study:
- To review and analyze recent research on the role of XIST in human tumor development.
- To elucidate the molecular mechanisms underlying XIST's function in oncogenesis.
Main Methods:
- Comprehensive literature review of studies on XIST in human cancers.
- Analysis of molecular functions and pathogenetic roles of XIST.
Main Results:
- XIST is frequently overexpressed and functions as an oncogene in numerous tumors.
- XIST impacts multiple stages of carcinogenesis, including tumor initiation, progression, and patient prognosis.
Conclusions:
- XIST plays a significant role in human tumor pathogenesis.
- Understanding XIST's multilevel molecular functions offers novel therapeutic and diagnostic strategies for cancer.
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