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Patent ductus arteriosus: From pharmacology to surgery

Jamie E Anderson1, Brian H Morray2, Mihai Puia-Dumitrescu3

  • 1Pediatric General and Thoracic Surgery, University of Washington Medical School, Seattle Children's Hospital, 4800 Sand Point Way NE, OA.9.220, Seattle, WA, USA.

Seminars in Pediatric Surgery
|December 21, 2021
PubMed

Insights

Patent ductus arteriosus (PDA) is common in premature infants. This review covers PDA pathophysiology and current medical, surgical, and endovascular treatments for closure.

Area of Science:

  • Neonatalogy
  • Pediatric Cardiology
  • Medical Device Technology

Background:

  • Patent ductus arteriosus (PDA) occurs in 0.1-0.2% of term infants.
  • Incidence is five-fold higher in premature infants, inversely related to birth weight and gestational age.
  • Persistent PDA can lead to significant short- and long-term health issues.

Purpose of the Study:

  • To summarize the pathophysiology of PDA.
  • To characterize current medical, surgical, and endovascular treatment approaches for PDA closure.

Main Methods:

  • Literature review of PDA pathophysiology.
  • Analysis of evolving medical and interventional PDA closure techniques.
  • Synthesis of treatment decision-making pathways.

Main Results:

  • PDA pathophysiology detailed, highlighting risks of left-to-right shunting.
  • Overview of medical management options for PDA.
  • Description of surgical and endovascular interventions for PDA closure.

Conclusions:

  • PDA management requires careful consideration of infant's condition.
  • Treatment strategies for PDA have advanced significantly.
  • This review provides a comprehensive overview of PDA pathophysiology and treatment.

Keywords:
Patent ductus arteriosusTranscatheter closure

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